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Fashion designer Donatella Versace lost her brother, Gianni Versace, in a tragic murder in 1997. Gianni was not only her sibling but also her mentor.
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In 2003, actor Mark Wahlberg experienced both joy and sorrow on the same day. He welcomed his first child into the world while also enduring the loss of his sister, Deborah Donnelly-Wahlberg, who suffered a heart attack at the age of 43.
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Tragically, in 2014, Julia Roberts' half-sister, Nancy Motes, ended her own life at the age of 37. Nancy had been a production assistant on the show 'Glee.' The loss of her half-sister marked a deeply painful and sorrowful chapter in Julia Roberts' life.
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Actor Keanu Reeves faced a series of personal tragedies, including losing his baby daughter, stillborn, and later losing his sister, Kim Reeves, to leukemia.
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Actress Kaley Cuoco lost her younger brother, Josh Cuoco, to unknown causes in 2014. She often honors his memory through social media posts and dedications.
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River Phoenix, the younger brother of Joaquin Phoenix, was a rising star in the Hollywood scene of his generation. Tragically, his promising life was abruptly ended in 1993 due to a fatal overdose at the age of 23. Heartbreakingly, Joaquin was present with his brother when the overdose occurred, making the loss even more poignant and haunting for him.
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Actress Courteney Cox lost her older brother, Richard Cox, to a rare bone cancer. The experience prompted her involvement in cancer awareness and support initiatives.
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Nick Carter, a member of the Backstreet Boys, experienced profound loss within his family. His sister Leslie passed away in 2012 at the age of 25 due to an overdose. Then, in November 2022, another tragedy struck as his younger brother Aaron, aged 34, tragically lost his life to drowning, with the cause attributed to inhaling difluoroethane and taking alprazolam.
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Media mogul Oprah Winfrey lost her half-sister, Patricia Lee Lloyd, in 2003 due to causes related to cocaine addiction. Oprah has spoken about the complex relationship they shared.
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The 'One Direction' member experienced a devastating loss when his 18-year-old sister Félicité passed away from heart failure in 2019. Tragically, their mother had succumbed to leukemia three years prior, making the singer and his sister no strangers to profound grief and adversity.
Tragedy has the ability to affect anyone, irrespective of their fame or wealth. These celebrities stand as proof to this truth, as their lives were irrevocably transformed by the heart-wrenching experience of losing a sibling.
Click through to find out which stars have tragically lost a sibling.