Kris Jenner is speaking candidly about her experience with Ozempic. During a new podcast appearance, the reality star and manager said she tried the drug before it became a major talking point in celebrity culture. The 70-year-old said the medication did not work well for her physically, leading her to stop and shift toward other wellness methods. According to Page Six, Jenner discussed the topic while also touching on her broader health habits, including regular testing and treatments she says help her maintain energy.

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Kris Jenner Says Ozempic Made Her Feel Sick

Jenner described trying semaglutide early, but the result was immediate discomfort. “We tried it once when no one knew what it was,” said Jenner according to Page Six. She did not explain when that happened or who she meant by “we.” She did, however, make clear why she moved on. Jenner said the drug made her “really sick” and “nauseous,” prompting her to look for another path. Her comments mark the first time she has publicly acknowledged using Ozempic after months of online speculation about her weight loss.

Kris Jenner Shares the Wellness Routine She Uses Now

Instead of continuing with Ozempic, Jenner said she now relies on peptide injections and supplements. She said those tools give her “more energy” and help create extra productive time in her day. Jenner also pointed to one habit she considers central to her health plan: frequent blood work. “I get my blood drawn every three months just to keep my hormones balanced because I realized after I was 45 that was important to your physical female health,” Jenner told Page Six. She added that checking thyroid and hormone levels helps show what the body needs.

2023 Photos Fueled Talk Around Her Weight Loss

Jenner’s comments arrive after a long stretch of public discussion around her appearance. In the summer of 2023, vacation photos posted to Instagram led to widespread chatter about whether Ozempic played a role in her slimmer look. At the time, social media users attached labels to her transformation, turning a private health topic into a public guessing game. Her new remarks do not answer every question about timing, but they do confirm that she had firsthand experience with the medication and that the side effects pushed her in another direction.

Khloé Kardashian and Scott Disick Faced Similar Drug Talk

The conversation has extended beyond Jenner. In January 2023, Khloé Kardashian pushed back after people claimed she was using a weight-loss drug, writing that critics should not dismiss her years of training. By late 2024, she took a less judgmental tone, saying people should do what helps them feel good. Scott Disick also entered the discussion after fans spotted Mounjaro in his fridge during an episode of the family’s Hulu series in 2024. In a 2025 episode, he defended his choice bluntly, while Kardashian said she understood the pressure tied to body image.