Prince Harry and Duchess Meghan are getting back to work in a big way.

It's been nearly four months since the couple welcomed their daughter Lilibet on June 4, but the royals have finally announced a new joint appearance — and it's in New York City, no less.

Prince Harry and Meghan's New York live show: Global Citizen

Fresh off their inclusion in TIME's 100 Most Influential People list, the Duke and Duchess will travel to New York City this week to promote vaccine equity at a show with the organization Global Citizen.

They'll appear this Saturday, Sept. 25, live from Central Park, where Global Citizen is putting on a star-studded event intended to "ensure vaccines are available to all" people around the world.

With the show, Harry and Meghan will "continue their urgent work with world leaders in the pursuit of global vaccine equity to end the COVID-19 pandemic for everyone, everywhere," Global Citizen writes.

Specifically, the organization is calling on "G7 countries and the European Union to immediately share at least 1 billion COVID-19 vaccine doses with those most in need."

Joining Harry and Meghan in the 24-hour live broadcast are names including Jennifer Lopez, Ed Sheeran, Elton John, and Coldplay, to name just a few.

Harry and Meghan back to work after baby Lilibet

Prince Harry previously attended the Global Citizen: Vax Live show back in May, when he received a standing ovation following a passionate speech on vaccines.

Prince Harry recording the "Vax Live Concert" 

But new appearances from the Duke and Duchess of Sussex had slowed in recent months, following the birth of their daughter on June 4. The couple took a parental leave after and had been limited to a few virtual appearances since then.

They'll be flying in to New York from California at some point this week. You can livestream their Sept. 25 show on services including YouTube, Twitter, Apple TV, and Global Citizen's website.