11 / 29
T.R. Knight
"George" still looks great. Even though, he 'only' was part of the main cast for five seasons, the fans still loved him and he has been featured in many different TV and big screen productions ever since. His last appearance was as "J. Edgar Hoover" on the TV drama 'Genius'.
12 / 29
Sandra Oh, Ellen Pompeo and Katherine Heigl
Sandra Oh was part of the main cast from the beginning and played "Dr. Christina Yang" for ten years, It was a shock for many fans, when she left the show!
13 / 29
Sandra Oh
By now, the actress is 52 years old and after 'Grey's Anatomy' had a recurring role in the third season of ABC's drama 'American Crime' in which she played "Abby Tanaka". She has been starring as "Eve Polastri" on 'Killing Eve', one of THE hit shows in recent years, and hosted the 2019 Golden Globe Awards.
14 / 29
Sara Ramirez
Sara Ramirez played the role of "Kelly Torres" since 2006. Of course, the actress has changed over the years. She was 29 when she started on Grey's Anatomy. She starred on the show from season 2 until the end of season 12.
15 / 29
Sara Ramirez
She still looks great today, at age 48! Ramirez joined the cast as a recurring character with the beginning of the second season and became part of the main cast until the end of the twelfth season. She played "Doctor Calliope Torres" for a total of 238 episodes. Ever since the end of her tenure, she had a recurring role in the CBS' drama 'Madam Secretary' from 2017 until 2019.
16 / 29
Chandra Wilson
Chandra Wilson has been starring as "Miranda Bailey" since 2005. By now, she is the Chief of Surgery!
17 / 29
Chandra Wilson
Chandra Wilson is now 54 years old and is one of three original cast members still starring on the show. The current "Chief of Surgery" is still just as bossy and hardcore as she was in season 1. Chandra WIlson has been in a relationship for over thirty years and she has three children.
18 / 29
James Pickens Jr.
James Pickens Jr. has been part of the main cast since 2005. For years, "Richard Webber" was only know as 'The Chief"! These days, "Richard" has taken a step back from surgery...
19 / 29
James Pickens Jr.
James Pickens is now 69 years old and has been a main cast member on 'Grey's Anatomy' since day one. Since 2018, he also has been playing the role of "Chuck Mitchell" in the show 'The Conners'.
20 / 29
Isaiah Washington
Isaiah Washington played the cardio surgeon "Preston Burke" for the first three seasons of the popular show. He had another guest appearance in season 10 of Grey's Anatomy.